An Expanded Registry of Candidate cis-Regulatory Elements

Welcome to the companion website for the ENCODE Registry of candidate cis-Regulatory Elements (cCREs).

This site highlights the main findings, design principles, and biological insights from the accompanying Nature article. It distills key results, addresses common questions, and provides context for how the Registry was built and how it can be used. Readers can explore major themes—such as cCRE classification, functional characterization, silencers, and variant interpretation—or jump directly to specific figures, resources, and datasets available through SCREEN. Together, the article and this site are intended to support transparent reuse of the Registry and to enable its application across diverse studies of gene regulation.