a, Barplots showing the percentage of distal enhancer cCREs with K562-specific STARR activity (K562 STARR+) belonging to each cCRE class called in K562 cells (using K562 chromatin signatures) and in HepG2 cells (using HepG2 chromatin signatures). b, Barplots showing the percentage of K562 STARR+ distal enhancer cCREs that overlap GATA1 motifs belonging to each cCRE class called in K562 cells and in HepG2 cells. c, Barplots showing the percentage of distal enhancer cCREs with HepG2-specific STARR activity (HepG2 STARR+) belonging to each cCRE class called in K562 cells (using K562 chromatin signatures) and in HepG2 cells (using HepG2 chromatin signatures). d, Barplots showing the percentage of HepG2 STARR+ distal enhancer cCREs that overlap HNF4A motifs belonging to each cCRE class called in K562 cells and in HepG2 cells. e, Barplots showing the percentage of HepG2 STARR+ distal enhancer cCREs that overlap p53 motifs belonging to each cCRE class called in K562 cells and in HepG2 cells. f, Barplots showing the percentage of HepG2 STARR+ distal enhancer cCREs that overlap GFI1B motifs belonging to each cCRE class called in K562 cells and in HepG2 cells. In all plots, the *** denotes p less than 0.001 as calculated by a chi-square test.