Supplementary Figure 20 : Characterizing MAFF/MAFK+ cCREs

Supplementary Figure 20 | Characterizing MAFF/MAFK+ cCREs

a, Heatscatter plot showing the distribution of MAFF/MAFK+ cCREs based on their alignment across Zoonomia mammalian genomes. N1 denotes the number of species in which ≥90% of a cCRE aligns; N2 denotes the number of species in which ≤10% of a cCRE aligns. Rectangles indicate predefined groups: Group 1 (G1), highly conserved (N1 ≥ 120, N2 ≤ 25); Group 2 (G2), actively evolving (20 ≤ N1 ≤ 50, N2 ≤ 120); and Group 3 (G3), primate-specific (N1 ≤ 50, N2 ≥ 180). b, Scatter plot depicting the enrichment of transcription factor peak summits at MAFF/MAFK+ enhancers in K562 compared to other K562 enhancers. Top enriched transcription factors are labeled. c, Genome browser shot of MAFF/MAFK+ cCRE EH38E1328964 that is a distal enhancer in K562 (top) but has low chromatin accessibility in HepG2.