Extended Data Figure 3 : STARR activity of cCREs is concordant with cell type-specific molecular profiles

Extended Data Figure 3 | STARR activity of cCREs is concordant with cell type-specific molecular profiles

a, Violin plots with embedded boxplots showing STARR scores for each of the K562 STARR+ distal enhancer cCREs that overlap GATA1 motifs (N = 610, left) and HepG2 STARR+ distal enhancer cCREs that overlap HNF4A (N = 1,021), TP53 (N=1,137), and GFI1B motifs (N = 781, right). STARR scores are from four whole-genome STARR-seq experiments including K562 (pink), HepG2 (green), HCT116 (gray), and MCF-7 (gray). Boxplots show the median (center line), interquartile range (IQR, box), and whiskers extending to the most extreme data points within 1.5× the IQR; outliers are omitted, and violins display the full distribution. P-values ADD p-values b, Barplots depicting gene expression in transcripts per million (TPM) of GATA1, HNF4A, TP53 and GFI1B, respectively, in K562 (pink), HepG2 (green), HCT116 (gray), and MCF-7 (gray) cell lines. One representative replicate from each RNA-seq experiment is displayed.