Extended Data Figure 1 : Increased biosample coverage of the Registry of cCREs

Extended Data Figure 1 | Increased biosample coverage of the Registry of cCREs

a, Body map denoting the number of biosamples in the ENCODE4 Registry of cCREs derived from each major organ or tissue. Organ/tissues in bold denote biosamples that are part of the core collection (i.e., have DNase, H3K4me3, H3K27ac, and CTCF). Numbers indicate the number of biosamples belonging to each category. The smaller blue body map represents the entire data production effort of ENCODE and the Roadmap Epigenomics Project (over 12,800 experiments), with the subset of experiments highlighted that were used to create the Registry of cCREs (more than 5,000 DNase, ATAC-seq, H3K4me3, H3K27ac, and CTCF ChIP-seq experiments). b, Barplots showing the number of biosamples in ENCODE3 and ENCODE4 versions of the Registry of cCREs, stratified by biosample type: tissues in red, primary cells in orange, organoids in yellow, in vitro differentiated cells in purple, and cell lines in blue. c, Barplots showing the number of biosamples in each version of the Registry of cCREs with all four core marks (DNase, H3K4me3, H3K27ac, and CTCF), stratified by biosample type and colored as defined in b.