Figure 2 : Functional characterization of the Registry of cCREs 

Figure 2 | Functional characterization of the Registry of cCREs. 

a, Scatterplot of CAPRA quantifications for distal enhancer cCREs in HepG2 vs. K562. Color of points indicates cCREs with enriched activity (STARR+) in HepG2 (green, N=5,246) or K562 (pink, N=1,892). b, Barplots of motif enrichment for HepG2 (green) or K562 (pink) STARR+ distal enhancers (as defined in a). Top five motifs are shown for each group of cCREs along with their corresponding logo. c, Genome browser view of three distal enhancer cCREs (denoted by 1-3) in the MTNR1A intron with DNase (green) and H3K27ac (yellow) signals in K562. A STARR-seq peak is shown in black. d, CAPRA quantifications for the three enhancers shown in c: EH38E3620077 (1), EH38E3620078 (2) and EH38E3620079 (3) using solo fragments (top) and double fragments (bottom). High quantifications are denoted in purple (CAPRA, p = 0.03). e, Overlap of common K562 transcription factor motifs at the three enhancers in c and d. Representative motif logos for EH38E3620078 and EH38E3620079 are shown.