a, Boxplots showing the percentage (left) and enrichment—compared to all cCREs—(right) of ENCODE4-specific cCREs that overlap BICCN cCREs with high DNase signals in different biosamples, stratified by tissue/organ of origin. Each point represents an individual biosample. b, Boxplots showing the percentage (left) and enrichment (right) of ENCODE4-specific cCREs that overlap union peaks from Loupe et al. with high DNase signals in different biosamples, stratified by tissue/organ of origin. c, Boxplots showing the percentage (left) and enrichment (right) of ENCODE4-specific cCREs that overlap tCREs from Li et al. with high DNase signals in different biosamples, stratified by tissue/organ of origin. d, Boxplots showing the percentage (left) and enrichment (right) of ENCODE4-specific cCREs that overlap acCREs from Zhang et al. with high DNase signals in different biosamples, stratified by biosample lifestage (embryonic vs. adult).