Supplementary Figure 17 : Silencer cCRE EH38E4193243 regulates PRDX2 via CTCF-Mediated chromatin interactions

Supplementary Figure 17 | Silencer cCRE EH38E4193243 regulates PRDX2 via CTCF-Mediated chromatin interactions

Genome browser view showing physical 3D genome interactions between silencer cCRE EH38E4193243 (pink highlight) and CTCF-anchor EH38E3291318 (blue highlight) with a domain of expressed genes. Targeting either silencer EH38E4193243 or CTCF-anchor EH38E3291318 results in increased expression of PRDX2 (dashed box). CTCF ChIA-PET links (dark blue) directly connect silencer EH38E4193243 with EH38E3291318. CTCF-anchor EH38E3291318 is also connected with upstream cCREs, forming a domain which brings silencer EH38E4193243 near the active promoters, as shown by RNAPII ChIA-PET links (dark red). Biochemical signals (DNase: green, H3K4me3: red, H3K27ac: yellow, CTCF: blue) and cCRE classifications for K562 cells are displayed.