Supplementary Figure 8 : Investigating GC content of promoter and enhancer cCREs

Supplementary Figure 8 | Investigating GC content of promoter and enhancer cCREs

a, Heatscatter depicting the number of biosamples with high DNase signal vs. GC content for promoter cCREs. b,  Heatscatter plot as in a, but for distal enhancer cCREs. c,  Scatterplot showing the relationship between GC preference score and promoter-binding preference for sequence-specific transcription factors, with each point representing a single ChIP-seq experiment in K562. The x-axis represents promoter-binding preference, defined as the log2 ratio of (% of peaks overlapping promoters / % overlapping enhancers) normalized by the promoter-to-enhancer ratio in K562. The y-axis shows the GC preference score, calculated by identifying the maximum log-odds score for guanine (G) or cytosine (C) at each motif position and averaging across all positions.