Supplementary Figure 10 : cCREs are enriched for cell type-specific functional activity

Supplementary Figure 10 | cCREs are enriched for cell type-specific functional activity

a, Barplot showing the percentage of active whole genome STARR-seq region (called peaks) that overlap K562 cCREs (pink), other cell type cCREs (black), and non-cCRE regions (gray). Numbers designate the number of regions in each category. b, Barplot depicting the percentage of cCRE or non-cCRE regions (as defined in a) that were tested in the assay that overlapped active whole genome STARR-seq regions. c, Barplot showing the percentage of K562 cCREs belonging to each class that were tested by STARR-seq. d, Barplot showing the percentage of STARR-seq active K562 cCREs belonging to each class.. e, Barplot showing the percentage of active MPRA regions (log2 fold change greater than one) that overlap K562 cCREs (pink), other cell type cCREs (black), and non-cCRE regions (gray). Numbers designate the number of regions in each category. f, Barplot depicting the percentage of cCRE or non-cCRE regions (as defined in e) that were tested in the assay that overlapped active MPRA regions. g, Barplot showing the percentage of K562 cCREs belonging to each class that were tested by MPRA. h, Barplot showing the percentage of MPRA active K562 cCREs belonging to each class. i, Barplot showing the percentage of active CRISPRi Flow-FISH regions (FDR < 0.05 ) that overlap K562 cCREs (pink), other cell type cCREs (black), and non-cCRE regions (gray). Numbers designate the number of regions in each category. j, Barplot depicting the percentage of cCRE or non-cCRE regions (as defined in i) that were tested in the assay that overlapped active CRISPRi Flow-FISH regions. k, Barplot showing the percentage of K562 cCREs belonging to each class that were tested by CRISPRi Flow-FISHc. l, Barplot showing the percentage of CRISPRi active K562 cCREs belonging to each class.